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Atomic force microscopy: A tool to study the structure, dynamics and stability of liposomal drug delivery systems

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dc.contributor.author Spyratou, E en
dc.contributor.author Mourelatou, EA en
dc.contributor.author Makropoulou, M en
dc.contributor.author Demetzos, C en
dc.date.accessioned 2014-03-01T11:44:49Z
dc.date.available 2014-03-01T11:44:49Z
dc.date.issued 2009 en
dc.identifier.issn 1742-5247 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/37186
dc.subject Atomic force microscopy en
dc.subject Drug delivery en
dc.subject Liposome en
dc.subject Stability en
dc.subject.classification Pharmacology & Pharmacy en
dc.subject.other dipalmitoylphosphatidylcholine en
dc.subject.other fluorouracil en
dc.subject.other liposome en
dc.subject.other paclitaxel en
dc.subject.other lipid en
dc.subject.other analytic method en
dc.subject.other atomic force microscopy en
dc.subject.other drug delivery system en
dc.subject.other drug stability en
dc.subject.other drug structure en
dc.subject.other dynamics en
dc.subject.other electron microscopy en
dc.subject.other liposomal delivery en
dc.subject.other microscopy en
dc.subject.other morphology en
dc.subject.other physical chemistry en
dc.subject.other review en
dc.subject.other scanning probe microscopy en
dc.subject.other chemistry en
dc.subject.other drug formulation en
dc.subject.other methodology en
dc.subject.other nanotechnology en
dc.subject.other pharmaceutics en
dc.subject.other surface property en
dc.subject.other Chemistry, Pharmaceutical en
dc.subject.other Drug Compounding en
dc.subject.other Lipids en
dc.subject.other Liposomes en
dc.subject.other Microscopy, Atomic Force en
dc.subject.other Nanotechnology en
dc.subject.other Surface Properties en
dc.subject.other Technology, Pharmaceutical en
dc.title Atomic force microscopy: A tool to study the structure, dynamics and stability of liposomal drug delivery systems en
heal.type other en
heal.identifier.primary 10.1517/17425240902828312 en
heal.identifier.secondary http://dx.doi.org/10.1517/17425240902828312 en
heal.language English en
heal.publicationDate 2009 en
heal.abstract Much work has been done during the past few decades to develop effective drug delivery systems (DDS), many of which are based on nanotechnology science. Liposomes are the most attractive lipid vesicles for drug delivery. The multifunctional properties of liposomes have a key role in modifying the bioavailability profile of a therapeutic agent. Different analytical techniques can be used to describe liposomes, not least applied scanning probe microscopy (SPM) techniques. Atomic force microscopy (AFM) seems to be one of the most effectively applied SPM techniques. This review article outlines the applications of AFM in evaluating the physical characteristics and stability of liposomal DDSs. Other well-known microscopy techniques used in evaluating liposome physical characteristics are also mentioned, and the contribution of AFM to evaluating liposomal stability is discussed. Among the advantages of AFM in examining the physicochemical properties of liposomal DDSs is its ability to provide morphological and metrology information on liposome properties. AFM thus appears to be a promising tool in technological characterization of liposomal DDSs. © 2009 Informa UK Ltd All rights reserved. en
heal.publisher INFORMA HEALTHCARE en
heal.journalName Expert Opinion on Drug Delivery en
dc.identifier.doi 10.1517/17425240902828312 en
dc.identifier.isi ISI:000265241200007 en
dc.identifier.volume 6 en
dc.identifier.issue 3 en
dc.identifier.spage 305 en
dc.identifier.epage 317 en


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