Atomic force microscopy: A tool to study the structure, dynamics and stability of liposomal drug delivery systems

Spyratou, E; Mourelatou, EA; Makropoulou, M; Demetzos, C

dc.contributor.author	Spyratou, E	en
dc.contributor.author	Mourelatou, EA	en
dc.contributor.author	Makropoulou, M	en
dc.contributor.author	Demetzos, C	en
dc.date.accessioned	2014-03-01T11:44:49Z
dc.date.available	2014-03-01T11:44:49Z
dc.date.issued	2009	en
dc.identifier.issn	1742-5247	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37186
dc.subject	Atomic force microscopy	en
dc.subject	Drug delivery	en
dc.subject	Liposome	en
dc.subject	Stability	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.other	dipalmitoylphosphatidylcholine	en
dc.subject.other	fluorouracil	en
dc.subject.other	liposome	en
dc.subject.other	paclitaxel	en
dc.subject.other	lipid	en
dc.subject.other	analytic method	en
dc.subject.other	atomic force microscopy	en
dc.subject.other	drug delivery system	en
dc.subject.other	drug stability	en
dc.subject.other	drug structure	en
dc.subject.other	dynamics	en
dc.subject.other	electron microscopy	en
dc.subject.other	liposomal delivery	en
dc.subject.other	microscopy	en
dc.subject.other	morphology	en
dc.subject.other	physical chemistry	en
dc.subject.other	review	en
dc.subject.other	scanning probe microscopy	en
dc.subject.other	chemistry	en
dc.subject.other	drug formulation	en
dc.subject.other	methodology	en
dc.subject.other	nanotechnology	en
dc.subject.other	pharmaceutics	en
dc.subject.other	surface property	en
dc.subject.other	Chemistry, Pharmaceutical	en
dc.subject.other	Drug Compounding	en
dc.subject.other	Lipids	en
dc.subject.other	Liposomes	en
dc.subject.other	Microscopy, Atomic Force	en
dc.subject.other	Nanotechnology	en
dc.subject.other	Surface Properties	en
dc.subject.other	Technology, Pharmaceutical	en
dc.title	Atomic force microscopy: A tool to study the structure, dynamics and stability of liposomal drug delivery systems	en
heal.type	other	en
heal.identifier.primary	10.1517/17425240902828312	en
heal.identifier.secondary	http://dx.doi.org/10.1517/17425240902828312	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Much work has been done during the past few decades to develop effective drug delivery systems (DDS), many of which are based on nanotechnology science. Liposomes are the most attractive lipid vesicles for drug delivery. The multifunctional properties of liposomes have a key role in modifying the bioavailability profile of a therapeutic agent. Different analytical techniques can be used to describe liposomes, not least applied scanning probe microscopy (SPM) techniques. Atomic force microscopy (AFM) seems to be one of the most effectively applied SPM techniques. This review article outlines the applications of AFM in evaluating the physical characteristics and stability of liposomal DDSs. Other well-known microscopy techniques used in evaluating liposome physical characteristics are also mentioned, and the contribution of AFM to evaluating liposomal stability is discussed. Among the advantages of AFM in examining the physicochemical properties of liposomal DDSs is its ability to provide morphological and metrology information on liposome properties. AFM thus appears to be a promising tool in technological characterization of liposomal DDSs. © 2009 Informa UK Ltd All rights reserved.	en
heal.publisher	INFORMA HEALTHCARE	en
heal.journalName	Expert Opinion on Drug Delivery	en
dc.identifier.doi	10.1517/17425240902828312	en
dc.identifier.isi	ISI:000265241200007	en
dc.identifier.volume	6	en
dc.identifier.issue	3	en
dc.identifier.spage	305	en
dc.identifier.epage	317	en