Multifunctional lipoic acid conjugates

Koufaki, M; Detsi, A; Kiziridi, C

dc.contributor.author	Koufaki, M	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Kiziridi, C	en
dc.date.accessioned	2014-03-01T11:44:59Z
dc.date.available	2014-03-01T11:44:59Z
dc.date.issued	2009	en
dc.identifier.issn	0929-8673	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37213
dc.subject	α-lipoic acid	en
dc.subject	Hybrids	en
dc.subject	Quantum dots	en
dc.subject	Self assembled monolayers	en
dc.subject.classification	Biochemistry & Molecular Biology	en
dc.subject.classification	Chemistry, Medicinal	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.other	2 (n,n dimethylamine)ethylamidolipoate	en
dc.subject.other	2,4 thiazolidinedione derivative	en
dc.subject.other	[1 [(1 formyl 2 phenylethyl)carbamoyl] 2 methylpropyl]carbamic acid benzyl ester	en
dc.subject.other	alpha tocopherol	en
dc.subject.other	antiinflammatory agent	en
dc.subject.other	antioxidant	en
dc.subject.other	bp 1003	en
dc.subject.other	bp 1008	en
dc.subject.other	bp 1009	en
dc.subject.other	bp 1010	en
dc.subject.other	bp 1017	en
dc.subject.other	calpastatin	en
dc.subject.other	dihydrolipoate	en
dc.subject.other	gold nanoparticle	en
dc.subject.other	lipocrine	en
dc.subject.other	melatoninolipoamide	en
dc.subject.other	nanocrystal	en
dc.subject.other	nanosphere	en
dc.subject.other	neuroprotective agent	en
dc.subject.other	placebo	en
dc.subject.other	quantum dot	en
dc.subject.other	quinolinone 3 aminocarboxamide derivative	en
dc.subject.other	rosiglitazone	en
dc.subject.other	thioctamide	en
dc.subject.other	thioctic acid	en
dc.subject.other	thioctic acid derivative	en
dc.subject.other	trisnorlipoic acid derivative	en
dc.subject.other	trolox C	en
dc.subject.other	trolox C thioctic acid conjugate	en
dc.subject.other	unclassified drug	en
dc.subject.other	unindexed drug	en
dc.subject.other	Alzheimer disease	en
dc.subject.other	antiinflammatory activity	en
dc.subject.other	antineoplastic activity	en
dc.subject.other	antioxidant activity	en
dc.subject.other	asthma	en
dc.subject.other	biological activity	en
dc.subject.other	clinical trial	en
dc.subject.other	concentration response	en
dc.subject.other	cosmetic industry	en
dc.subject.other	drug design	en
dc.subject.other	drug mechanism	en
dc.subject.other	drug potency	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	drug targeting	en
dc.subject.other	enzyme inhibition	en
dc.subject.other	heart protection	en
dc.subject.other	human	en
dc.subject.other	nerve cell lesion	en
dc.subject.other	neuroprotection	en
dc.subject.other	non insulin dependent diabetes mellitus	en
dc.subject.other	nonhuman	en
dc.subject.other	paw edema	en
dc.subject.other	pharmacophore	en
dc.subject.other	protein function	en
dc.subject.other	review	en
dc.subject.other	semiconductor	en
dc.subject.other	skin allergy	en
dc.subject.other	structure activity relation	en
dc.subject.other	synthesis	en
dc.subject.other	Anti-Inflammatory Agents	en
dc.subject.other	Antineoplastic Agents	en
dc.subject.other	Cosmetics	en
dc.subject.other	Drug Carriers	en
dc.subject.other	Hypoglycemic Agents	en
dc.subject.other	Nanospheres	en
dc.subject.other	Neuroprotective Agents	en
dc.subject.other	Quantum Dots	en
dc.subject.other	Thioctic Acid	en
dc.title	Multifunctional lipoic acid conjugates	en
heal.type	other	en
heal.identifier.primary	10.2174/092986709789878274	en
heal.identifier.secondary	http://dx.doi.org/10.2174/092986709789878274	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Several hundreds of studies published the last decade have reported that α-lipoic acid (LA) possesses the potential to intervene in various therapeutically interesting pathways. However, it should be noted that LA reportedly exerts most of its effects at high micromolar concentrations; that amides of LA exhibit higher biological activity than the parent compound; and that molecular combinations (hybrids) obtained by coupling LA with an amino-substituted bioactive moiety, possess multifunctional activity. The design and synthesis of hybrid molecules encompassing two pharmacophores in one molecular scaffold is a well established approach to the synthesis of more potent drugs with dual activity. Using this approach, various research groups have recently designed and synthesized LA containing hybrid compounds with antioxidant activity hyphenated with a wide variety of other activities such as neuroprotective, cardioprotective, anti-inflammatory, antidiabetic and anticancer activity as well as enzyme inhibition. Moreover, LA represents an ideal chemical entity for the development of biologically interesting functionalized nanoparticles. Many recent publications describe the use of LA: i) as component of nanospheres and nanoprodrugs, ii) as a linker for the attachment of lipids, carbohydrates, proteins and oligonucleotides on gold nanoparticles to form Self Assembled Monolayers (SAMs) and iii) as surface ligand for cap exchange reactions to prepare water-soluble semiconducting nanocrystal Quantum Dots (QDs). This review is focused on the growing field of the design and synthesis of LA conjugates, for the development of novel molecules with a dual mode of action and the construction of nanosized antioxidants, Self Assembled Monolayers and Quantum Dots. © 2009 Bentham Science Publishers Ltd.	en
heal.publisher	BENTHAM SCIENCE PUBL LTD	en
heal.journalName	Current Medicinal Chemistry	en
dc.identifier.doi	10.2174/092986709789878274	en
dc.identifier.isi	ISI:000272758000010	en
dc.identifier.volume	16	en
dc.identifier.issue	35	en
dc.identifier.spage	4728	en
dc.identifier.epage	4742	en