Role of oxidative stress and DNA damage in human carcinogenesis

Kryston, TB; Georgiev, AB; Pissis, P; Georgakilas, AG

dc.contributor.author	Kryston, TB	en
dc.contributor.author	Georgiev, AB	en
dc.contributor.author	Pissis, P	en
dc.contributor.author	Georgakilas, AG	en
dc.date.accessioned	2014-03-01T11:45:11Z
dc.date.available	2014-03-01T11:45:11Z
dc.date.issued	2011	en
dc.identifier.issn	0027-5107	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37278
dc.subject	Biomarkers	en
dc.subject	Cancer	en
dc.subject	DNA damage repair	en
dc.subject	Free radicals	en
dc.subject	Oxidative stress	en
dc.subject.classification	Biotechnology & Applied Microbiology	en
dc.subject.classification	Genetics & Heredity	en
dc.subject.classification	Toxicology	en
dc.subject.other	8 hydroxyguanine	en
dc.subject.other	reactive nitrogen species	en
dc.subject.other	reactive oxygen metabolite	en
dc.subject.other	carcinogenesis	en
dc.subject.other	cell death	en
dc.subject.other	chromosomal instability	en
dc.subject.other	chronic inflammation	en
dc.subject.other	conformational transition	en
dc.subject.other	DNA damage	en
dc.subject.other	DNA repair	en
dc.subject.other	double stranded DNA break	en
dc.subject.other	excision repair	en
dc.subject.other	genomic instability	en
dc.subject.other	human	en
dc.subject.other	lipid peroxidation	en
dc.subject.other	nonhuman	en
dc.subject.other	oxidative stress	en
dc.subject.other	priority journal	en
dc.subject.other	review	en
dc.subject.other	single stranded DNA break	en
dc.subject.other	tumor growth	en
dc.subject.other	tumor microenvironment	en
dc.subject.other	Biological Markers	en
dc.subject.other	DNA Damage	en
dc.subject.other	DNA Repair	en
dc.subject.other	Humans	en
dc.subject.other	Neoplasms	en
dc.subject.other	Oxidative Stress	en
dc.subject.other	Reactive Oxygen Species	en
dc.title	Role of oxidative stress and DNA damage in human carcinogenesis	en
heal.type	other	en
heal.identifier.primary	10.1016/j.mrfmmm.2010.12.016	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.mrfmmm.2010.12.016	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	Cells in tissues and organs are continuously subjected to oxidative stress and free radicals on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin. The cells withstand and counteract this occurrence by the use of several and different defense mechanisms ranging from free radical scavengers like glutathione (GSH), vitamins C and E and antioxidant enzymes like catalase, superoxide dismutase and various peroxidases to sophisticated and elaborate DNA repair mechanisms. The outcome of this dynamic equilibrium is usually the induction of oxidatively induced DNA damage and a variety of lesions of small to high importance and dangerous for the cell i.e. isolated base lesions or single strand breaks (SSBs) to complex lesions like double strand breaks (DSBs) and other non-DSB oxidatively generated clustered DNA lesions (OCDLs). The accumulation of DNA damage through mis-repair or incomplete repair may lead to mutagenesis and consequently transformation particularly if combined with a deficient apoptotic pathway. In this review, we present the current status of knowledge and evidence on the mechanisms and involvement of intracellular oxidative stress and DNA damage in human malignancy evolution and possible use of these parameters as cancer biomarkers. At the same time, we discuss controversies related to potential artifacts inherent to specific methodologies used for the measurement of oxidatively induced DNA lesions in human cells or tissues. (C) 2011 Elsevier B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis	en
dc.identifier.doi	10.1016/j.mrfmmm.2010.12.016	en
dc.identifier.isi	ISI:000291914700020	en
dc.identifier.volume	711	en
dc.identifier.issue	1-2	en
dc.identifier.spage	193	en
dc.identifier.epage	201	en