Role of oxidative stress and DNA damage in human carcinogenesis

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dc.contributor.author Kryston, TB en
dc.contributor.author Georgiev, AB en
dc.contributor.author Pissis, P en
dc.contributor.author Georgakilas, AG en
dc.date.accessioned 2014-03-01T11:45:11Z
dc.date.available 2014-03-01T11:45:11Z
dc.date.issued 2011 en
dc.identifier.issn 0027-5107 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/37278
dc.subject Biomarkers en
dc.subject Cancer en
dc.subject DNA damage repair en
dc.subject Free radicals en
dc.subject Oxidative stress en
dc.subject.classification Biotechnology & Applied Microbiology en
dc.subject.classification Genetics & Heredity en
dc.subject.classification Toxicology en
dc.subject.other 8 hydroxyguanine en
dc.subject.other reactive nitrogen species en
dc.subject.other reactive oxygen metabolite en
dc.subject.other carcinogenesis en
dc.subject.other cell death en
dc.subject.other chromosomal instability en
dc.subject.other chronic inflammation en
dc.subject.other conformational transition en
dc.subject.other DNA damage en
dc.subject.other DNA repair en
dc.subject.other double stranded DNA break en
dc.subject.other excision repair en
dc.subject.other genomic instability en
dc.subject.other human en
dc.subject.other lipid peroxidation en
dc.subject.other nonhuman en
dc.subject.other oxidative stress en
dc.subject.other priority journal en
dc.subject.other review en
dc.subject.other single stranded DNA break en
dc.subject.other tumor growth en
dc.subject.other tumor microenvironment en
dc.subject.other Biological Markers en
dc.subject.other DNA Damage en
dc.subject.other DNA Repair en
dc.subject.other Humans en
dc.subject.other Neoplasms en
dc.subject.other Oxidative Stress en
dc.subject.other Reactive Oxygen Species en
dc.title Role of oxidative stress and DNA damage in human carcinogenesis en
heal.type other en
heal.identifier.primary 10.1016/j.mrfmmm.2010.12.016 en
heal.identifier.secondary http://dx.doi.org/10.1016/j.mrfmmm.2010.12.016 en
heal.language English en
heal.publicationDate 2011 en
heal.abstract Cells in tissues and organs are continuously subjected to oxidative stress and free radicals on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin. The cells withstand and counteract this occurrence by the use of several and different defense mechanisms ranging from free radical scavengers like glutathione (GSH), vitamins C and E and antioxidant enzymes like catalase, superoxide dismutase and various peroxidases to sophisticated and elaborate DNA repair mechanisms. The outcome of this dynamic equilibrium is usually the induction of oxidatively induced DNA damage and a variety of lesions of small to high importance and dangerous for the cell i.e. isolated base lesions or single strand breaks (SSBs) to complex lesions like double strand breaks (DSBs) and other non-DSB oxidatively generated clustered DNA lesions (OCDLs). The accumulation of DNA damage through mis-repair or incomplete repair may lead to mutagenesis and consequently transformation particularly if combined with a deficient apoptotic pathway. In this review, we present the current status of knowledge and evidence on the mechanisms and involvement of intracellular oxidative stress and DNA damage in human malignancy evolution and possible use of these parameters as cancer biomarkers. At the same time, we discuss controversies related to potential artifacts inherent to specific methodologies used for the measurement of oxidatively induced DNA lesions in human cells or tissues. (C) 2011 Elsevier B.V. All rights reserved. en
heal.publisher ELSEVIER SCIENCE BV en
heal.journalName Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis en
dc.identifier.doi 10.1016/j.mrfmmm.2010.12.016 en
dc.identifier.isi ISI:000291914700020 en
dc.identifier.volume 711 en
dc.identifier.issue 1-2 en
dc.identifier.spage 193 en
dc.identifier.epage 201 en

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