Mastocytosis with skin manifestations: current status

Katsambas, AD; Karpouzis, AJ; Koumantaki-Mathioudaki, E; Jorizzo, JL

dc.contributor.author	Katsambas, AD	en
dc.contributor.author	Karpouzis, AJ	en
dc.contributor.author	Koumantaki-Mathioudaki, E	en
dc.contributor.author	Jorizzo, JL	en
dc.date.accessioned	2014-03-01T11:45:43Z
dc.date.available	2014-03-01T11:45:43Z
dc.date.issued	1999	en
dc.identifier.issn	0926-9959	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37583
dc.subject	mastocytosis	en
dc.subject	mast cell	en
dc.subject.classification	Dermatology	en
dc.subject.other	MAST-CELL DISEASE	en
dc.subject.other	MACULARIS-ERUPTIVA-PERSTANS	en
dc.subject.other	BONE-MARROW FINDINGS	en
dc.subject.other	URTICARIA-PIGMENTOSA	en
dc.subject.other	SYSTEMIC MASTOCYTOSIS	en
dc.subject.other	CUTANEOUS MASTOCYTOSIS	en
dc.subject.other	ADHESION MOLECULES	en
dc.subject.other	TOPICAL STEROIDS	en
dc.subject.other	PROGENITOR CELLS	en
dc.subject.other	CATHEPSIN-G	en
dc.title	Mastocytosis with skin manifestations: current status	en
heal.type	other	en
heal.language	English	en
heal.publicationDate	1999	en
heal.abstract	Aim To review our present knowledge about mastocyte origin, mastocytosis classification and management. Methods Literature review. Results Mastocytoses are chronic and recurrent disorders with symptoms which might either be Limited only to the skin or to internal organs as well. The mastocytes, coming from bone marrow progenitor cells, migrate to tissues where they participate in inflammation and in cellular immunity as well as in the metabolism of connective and osseous tissues. Their proliferation causes the appearance of mastocytoses. The classification of the clinical manifestations of the mastocytoses into cutaneous, reactive (under the influence of the degranulator factors) and systemic disease, facilitates dialog among clinicians. Determination of prognosis and appropriate therapeutic regimens depend on individual features. Conclusions Mastocytosis diagnosis is verified by histological study of skin lesion biopsy material. Management is symptomatic and unfortunately does not eradicate the disease. (C) 1999 Elsevier Science B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY	en
dc.identifier.isi	ISI:000084840600001	en
dc.identifier.volume	13	en
dc.identifier.issue	3	en
dc.identifier.spage	155	en
dc.identifier.epage	165	en