Retrograde cardioplegia in CABG: Is it really useful? The microcirculation and a capillary unit model

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dc.contributor.author Kouerinis, IA en
dc.contributor.author Manopoulos, CG en
dc.contributor.author Zografos, GC en
dc.contributor.author Apostolakis, EI en
dc.contributor.author Tsilimingas, NB en
dc.contributor.author Argiriou, ME en
dc.contributor.author Gorgoulis, VG en
dc.contributor.author Dedeilias, PG en
dc.contributor.author Tsoukas, A en
dc.contributor.author Bolos, K en
dc.contributor.author Tsangaris, SG en
dc.date.accessioned 2014-03-01T11:46:15Z
dc.date.available 2014-03-01T11:46:15Z
dc.date.issued 2006 en
dc.identifier.issn 1234-1010 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/37747
dc.subject retrograde cardioplegia en
dc.subject CABG surgery en
dc.subject capillary anatomy en
dc.subject collateral blood flow en
dc.subject myocardial protection en
dc.subject.classification Medicine, Research & Experimental en
dc.subject.other CORONARY SINUS OCCLUSION en
dc.subject.other COLLATERALS en
dc.subject.other ANTEGRADE en
dc.subject.other PRESSURE en
dc.subject.other HEARTS en
dc.title Retrograde cardioplegia in CABG: Is it really useful? The microcirculation and a capillary unit model en
heal.type other en
heal.language English en
heal.publicationDate 2006 en
heal.abstract Most surgeons, ourselves including, use retrograde cardioplegia in numerable operations in cardiac surgery. It is believed to be not only supplementary to antegrade, but also a unique alternative in special complicated cases. Regarding CABGs (coronary artery bypass grafts), many authors advocate its routine use together with antegrade, while others do not suggest it for standard practice. The existing disagreement on this special item is consequential to the different results among various protocols which have studied the effect of antegrade and retrograde perfusion. In these studies, fundamental variations in design, materials, and methods have resulted in an inability to compare results. Additionally, most of the published protocols studying cardioplegic arrest offer only a gross estimation of the microcirculatory perfusion, which is the basis of myocardial protection. Our present review is an attempt to elucidate the differences, explain the necessity of comparing retrograde cardioplegia alone with antegrade in CABGs for the reproduction of safe results, clarify the role of Thebesian veins and venovenous connections during retroperfusion, consider the critical anatomic differences between human hearts and those of animals which may result in serious study bias, and, finally, offer an explanation of what may really be going on in the microcirculation during antegrade and retrograde perfusion using a human capillary model. en
dc.identifier.isi ISI:000242137900020 en
dc.identifier.volume 12 en
dc.identifier.issue 11 en
dc.identifier.spage RA265 en
dc.identifier.epage RA268 en

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