Clinical, immunologic, and molecular factors predicting lymphoma development in Sjogren's syndrome patients

Voulgarelis, M; Skopouli, FN

dc.contributor.author	Voulgarelis, M	en
dc.contributor.author	Skopouli, FN	en
dc.date.accessioned	2014-03-01T11:46:17Z
dc.date.available	2014-03-01T11:46:17Z
dc.date.issued	2007	en
dc.identifier.issn	1080-0549	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37774
dc.subject	Sjogren's syndrome	en
dc.subject	lymphoma	en
dc.subject	lymphoproliferation	en
dc.subject	predictive factors	en
dc.subject	prelymphomatous stage	en
dc.subject	autoimmunity	en
dc.subject.classification	Allergy	en
dc.subject.classification	Immunology	en
dc.subject.other	SALIVARY-GLAND LYMPHOMAS	en
dc.subject.other	CROSS-REACTIVE IDIOTYPES	en
dc.subject.other	GASTRIC MALT-LYMPHOMA	en
dc.subject.other	NON-HODGKINS-LYMPHOMA	en
dc.subject.other	B-CELL LYMPHOMAS	en
dc.subject.other	MALIGNANT-LYMPHOMA	en
dc.subject.other	RHEUMATOID-FACTOR	en
dc.subject.other	TISSUE LYMPHOMA	en
dc.subject.other	MONOCLONAL IMMUNOGLOBULINS	en
dc.subject.other	AUTOIMMUNE-DISEASES	en
dc.title	Clinical, immunologic, and molecular factors predicting lymphoma development in Sjogren's syndrome patients	en
heal.type	other	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Among autoimmune diseases, Sjogren's syndrome (SS) displays the highest incidence of non-Hodgkin lymphoma (NHL) development with the salivary extranodal marginal zone B cell lymphomas being the most common type. The majority of SS-associated NHLs are characterized by localized stage, indolent clinical course, and recurrence in other extranodal sites. Although the transition from a chronic inflammatory condition to malignant lymphoma is a multistep process yet poorly understood, there is increasing evidence that chronic antigenic stimulation by an exoantigen or autoantigens plays an essential role in the development of SS associated lymphoproliferation. Additional molecular oncogenic events such as microsatellite instability, loss of the B cell cycle control, and the forced overproduction of specific B cell biologic stimulators seem to contribute to the emergence and progression of the malignant overgrowth. Among the clinical and serological parameters that have been associated with lymphoma development in SS patients, the presence of palpable purpura, low C4, and mixed monoclonal cryoglobulinemia constitute the main predictive markers, and patients displaying these risk factors should be monitored closely.	en
heal.publisher	HUMANA PRESS INC	en
heal.journalName	CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY	en
dc.identifier.isi	ISI:000251150600009	en
dc.identifier.volume	32	en
dc.identifier.issue	3	en
dc.identifier.spage	265	en
dc.identifier.epage	274	en