Persistent viral infection in primary Sjogren's syndrome: Review and perspectives

Triantafyllopoulou, A; Moutsopoulos, H

dc.contributor.author	Triantafyllopoulou, A	en
dc.contributor.author	Moutsopoulos, H	en
dc.date.accessioned	2014-03-01T11:46:18Z
dc.date.available	2014-03-01T11:46:18Z
dc.date.issued	2007	en
dc.identifier.issn	1080-0549	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37792
dc.subject	primary Sjogren's syndrome	en
dc.subject	autoimmunity	en
dc.subject	persistent viral infection	en
dc.subject	coxsackieviruses	en
dc.subject	epithelial cell activation	en
dc.subject.classification	Allergy	en
dc.subject.classification	Immunology	en
dc.subject.other	EPSTEIN-BARR-VIRUS	en
dc.subject.other	POLYMERASE CHAIN-REACTION	en
dc.subject.other	SALIVARY-GLAND BIOPSIES	en
dc.subject.other	COXSACKIEVIRUS INFECTION	en
dc.subject.other	EPITHELIAL-CELLS	en
dc.subject.other	DNA	en
dc.subject.other	AUTOIMMUNITY	en
dc.subject.other	EXPRESSION	en
dc.subject.other	RETROVIRUS	en
dc.subject.other	ALPHA	en
dc.title	Persistent viral infection in primary Sjogren's syndrome: Review and perspectives	en
heal.type	other	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Exocrine gland pathology in primary Sjogren's syndrome is characterized by destruction of acinar epithelial cells and chronic lymphocytic infiltrates surrounding ductal epithelial cells. These cells seem to be activated, as it is inferred by their immunophenotype. The cause of this activation and the chronic inflammatory response that targets epithelial cells remain unknown. Here, we will review the evidence pointing to a persistent viral infection as a probable cause of primary Sjogren's syndrome and discuss potential directions for future research.	en
heal.publisher	HUMANA PRESS INC	en
heal.journalName	CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY	en
dc.identifier.isi	ISI:000251150600003	en
dc.identifier.volume	32	en
dc.identifier.issue	3	en
dc.identifier.spage	210	en
dc.identifier.epage	214	en