Sjogren's syndrome - Study of autoantigens and autoantibodies

Routsias, JG; Tzioufas, AG

dc.contributor.author	Routsias, JG	en
dc.contributor.author	Tzioufas, AG	en
dc.date.accessioned	2014-03-01T11:46:18Z
dc.date.available	2014-03-01T11:46:18Z
dc.date.issued	2007	en
dc.identifier.issn	1080-0549	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37798
dc.subject	Sjogren's syndrome	en
dc.subject	autoantigens	en
dc.subject	Ro(SS-A)	en
dc.subject	La(SS-B)	en
dc.subject	carbonic anhydrase	en
dc.subject	fodrin	en
dc.subject	poly(ADP)ribose polymerase	en
dc.subject	muscarinic receptor	en
dc.subject.classification	Allergy	en
dc.subject.classification	Immunology	en
dc.subject.other	ALPHA-FODRIN ANTIBODIES	en
dc.subject.other	B-CELL EPITOPES	en
dc.subject.other	MUSCARINIC ACETYLCHOLINE-RECEPTORS	en
dc.subject.other	SYSTEMIC-LUPUS-ERYTHEMATOSUS	en
dc.subject.other	CARBONIC-ANHYDRASE-II	en
dc.subject.other	POLY(ADENOSINE DIPHOSPHATE-RIBOSE) POLYMERASE	en
dc.subject.other	RO RIBONUCLEOPROTEIN COMPLEXES	en
dc.subject.other	PRIMARY BILIARY-CIRRHOSIS	en
dc.subject.other	CROSS-REACTIVE IDIOTYPES	en
dc.subject.other	CONGENITAL HEART-BLOCK	en
dc.title	Sjogren's syndrome - Study of autoantigens and autoantibodies	en
heal.type	other	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	The presence of autoantibodies is the hallmark of systemic autoimmune diseases. During the past 30 years, intense clinical and basic research have dissected the clinical value of autoantibodies in many autoimmune diseases and offered new insights into a better understanding of the molecular and functional properties of the targeted autoantigens. Unraveling the immunologic mechanisms underlying the autoimmune tissue injury, provided useful conclusions on the generation of autoantibodies and the perpetuation of the autoimmune response. Primary Sjogren's syndrome (pSS) is characterized by the presence of autoantibodies binding on a vast array of organ and non-organ specific autoantigens. The most common autoantibodies are those targeting the Ro/La RNP complex, and they serve as disease markers, as they are included in the European-American Diagnostic Criteria for pSS. Other autoantibodies are associated with particular disease manifestations, such as anti-centromere antibodies with Raynaud's phenomenon, anti-carbonic anhydrase II with distal renal tubular acidosis, anti-mitochondrial antibodies with liver pathology, and cryoglobulins with the evolution to non-Hodgkin's lymphoma. Finally, autoantibodies against autoantigens such as alpha- and beta-fodrin, islet cell autoantigen, poly(ADP)ribose polymerase (PARP), NuMA, Golgins, and NOR-90 are found in a subpopulation of SS patients without disease specificity, and their utility remains to be elucidated. In this review, the molecular and clinical characteristics (divided according to their clinical utility) of the autoantigens and autoantibodies associated with pSS are discussed.	en
heal.publisher	HUMANA PRESS INC	en
heal.journalName	CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY	en
dc.identifier.isi	ISI:000251150600007	en
dc.identifier.volume	32	en
dc.identifier.issue	3	en
dc.identifier.spage	238	en
dc.identifier.epage	251	en