The role of epithelial cells in the pathogenesis of Sjogren's syndrome

Manoussakis, MN; Kapsogeorgou, EK

dc.contributor.author	Manoussakis, MN	en
dc.contributor.author	Kapsogeorgou, EK	en
dc.date.accessioned	2014-03-01T11:46:19Z
dc.date.available	2014-03-01T11:46:19Z
dc.date.issued	2007	en
dc.identifier.issn	1080-0549	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37801
dc.subject	Sjogren's syndrome	en
dc.subject	epithelial cells	en
dc.subject	salivary gland	en
dc.subject	immune regulation	en
dc.subject	intrinsic activation	en
dc.subject.classification	Allergy	en
dc.subject.classification	Immunology	en
dc.subject.other	MESSENGER-RNA EXPRESSION	en
dc.subject.other	SALIVARY-GLAND TISSUES	en
dc.subject.other	HEPATITIS-C VIRUS	en
dc.subject.other	HLA-DR EXPRESSION	en
dc.subject.other	COSTIMULATORY MOLECULES	en
dc.subject.other	AUTOANTIBODY PRODUCTION	en
dc.subject.other	AUTOIMMUNE EPITHELITIS	en
dc.subject.other	LYMPHOID ORGANIZATION	en
dc.subject.other	CIRCULATING LEVELS	en
dc.subject.other	ENDOTHELIAL-CELLS	en
dc.title	The role of epithelial cells in the pathogenesis of Sjogren's syndrome	en
heal.type	other	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Sjogren's syndrome (SS) is a chronic autoimmune exocrinopathy that is characterized by periductal mononuclear cell infiltrates in the affected exocrine glands. Epithelial cells are thought to play an important pathogenetic role, as suggested by the occurrence of infiltrating lesions in various epithelial tissues (described as autoimmune epithelitis) as well as the increased epithelial expression of several inflammatory proteins in the histopathologic lesions of patients. In the recent decade, the application of long-term cultured nonneoplastic salivary gland epithelial cell (SGEC) lines has permitted the more explicit analysis of the role of these cells in SS pathophysiology. In such studies, cultured SGEC have been demonstrated to express constitutively or inducibly various molecules that are implicated in innate and acquired immune responses, a fact that underscores the inherent capacity of these epithelial cells to induce and promote chronic inflammatory reactions. Furthermore, the parallel analysis of SGEC lines obtained from SS patients and disease controls has revealed the significantly increased constitutive expression of several molecules in cells derived from SS patients. This fact strongly suggests the operation of intrinsic activation mechanisms in the epithelia of patients and further supports the active participation of epithelia in SS pathogenesis.	en
heal.publisher	HUMANA PRESS INC	en
heal.journalName	CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY	en
dc.identifier.isi	ISI:000251150600005	en
dc.identifier.volume	32	en
dc.identifier.issue	3	en
dc.identifier.spage	225	en
dc.identifier.epage	230	en