The diagnosis and management of parasellar tumours of the pituitary

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Kaltsas, GA en
dc.contributor.author Evanson, J en
dc.contributor.author Chrisoulidou, A en
dc.contributor.author Grossman, AB en
dc.date.accessioned 2014-03-01T11:46:21Z
dc.date.available 2014-03-01T11:46:21Z
dc.date.issued 2008 en
dc.identifier.issn 1351-0088 en
dc.identifier.uri http://hdl.handle.net/123456789/37840
dc.subject.classification Oncology en
dc.subject.classification Endocrinology & Metabolism en
dc.subject.other GERM-CELL TUMORS en
dc.subject.other CENTRAL-NERVOUS-SYSTEM en
dc.subject.other OF-THE-LITERATURE en
dc.subject.other BRAIN-TUMORS en
dc.subject.other COOPERATIVE TRIAL en
dc.subject.other RADIATION-THERAPY en
dc.subject.other SELLAR REGION en
dc.subject.other SKULL-BASE en
dc.subject.other CRANIOPHARYNGIOMAS en
dc.title The diagnosis and management of parasellar tumours of the pituitary en
heal.type other en
heal.language English en
heal.publicationDate 2008 en
heal.abstract The sellar and parasellar region is an anatomically complex area where a number of neoplastic, inflammatory, infectious, developmental and vascular diseases can develop. Although most sellar lesions are due to pituitary adenomas, a number of other pathologies involving the parasellar region can present in a similar manner. The diagnosis of such lesions involves a multidisciplinary approach, and detailed endocrinological, ophthalmological, neuroimaging, neurological and finally histological studies are required. Correct diagnosis prior to any intervention is essential as the treatment of choice will be different for each disorder, particularly in the case of primary malignant parasellar tumours. The complexity of structures that define the parasellar region can produce a variety of neoplastic processes, the malignant potential of which relies on histological grading. In the majority of parasellar tumours, a multimodal therapeutic approach is frequently necessary including surgery, radiotherapy, primary or adjuvant medical treatment and replacement of apparent endocrine deficits. Disease-specific medical therapies are mandatory in order to prevent recurrence or further tumour growth. This is particularly important as neoplastic lesions of the parasellar region tend to recur after prolonged follow-up, even when optimally treated. Apart from the type of treatment, identification of clinical and radiological features that could predict patients with different prognosis seems necessary in order to identify high-risk patients. Due to their rarity, central registration of parasellar tumours is required in order to be able to provide evidence-based diagnostic and mainly therapeutic approaches. en
heal.publisher BIOSCIENTIFICA LTD en
dc.identifier.isi ISI:000262590500004 en
dc.identifier.volume 15 en
dc.identifier.issue 4 en
dc.identifier.spage 885 en
dc.identifier.epage 903 en

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record