The diagnosis and management of parasellar tumours of the pituitary

Kaltsas, GA; Evanson, J; Chrisoulidou, A; Grossman, AB

dc.contributor.author	Kaltsas, GA	en
dc.contributor.author	Evanson, J	en
dc.contributor.author	Chrisoulidou, A	en
dc.contributor.author	Grossman, AB	en
dc.date.accessioned	2014-03-01T11:46:21Z
dc.date.available	2014-03-01T11:46:21Z
dc.date.issued	2008	en
dc.identifier.issn	1351-0088	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37840
dc.subject.classification	Oncology	en
dc.subject.classification	Endocrinology & Metabolism	en
dc.subject.other	GERM-CELL TUMORS	en
dc.subject.other	CENTRAL-NERVOUS-SYSTEM	en
dc.subject.other	OF-THE-LITERATURE	en
dc.subject.other	BRAIN-TUMORS	en
dc.subject.other	MALIGNANT TRANSFORMATION	en
dc.subject.other	COOPERATIVE TRIAL	en
dc.subject.other	RADIATION-THERAPY	en
dc.subject.other	SELLAR REGION	en
dc.subject.other	SKULL-BASE	en
dc.subject.other	CRANIOPHARYNGIOMAS	en
dc.title	The diagnosis and management of parasellar tumours of the pituitary	en
heal.type	other	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	The sellar and parasellar region is an anatomically complex area where a number of neoplastic, inflammatory, infectious, developmental and vascular diseases can develop. Although most sellar lesions are due to pituitary adenomas, a number of other pathologies involving the parasellar region can present in a similar manner. The diagnosis of such lesions involves a multidisciplinary approach, and detailed endocrinological, ophthalmological, neuroimaging, neurological and finally histological studies are required. Correct diagnosis prior to any intervention is essential as the treatment of choice will be different for each disorder, particularly in the case of primary malignant parasellar tumours. The complexity of structures that define the parasellar region can produce a variety of neoplastic processes, the malignant potential of which relies on histological grading. In the majority of parasellar tumours, a multimodal therapeutic approach is frequently necessary including surgery, radiotherapy, primary or adjuvant medical treatment and replacement of apparent endocrine deficits. Disease-specific medical therapies are mandatory in order to prevent recurrence or further tumour growth. This is particularly important as neoplastic lesions of the parasellar region tend to recur after prolonged follow-up, even when optimally treated. Apart from the type of treatment, identification of clinical and radiological features that could predict patients with different prognosis seems necessary in order to identify high-risk patients. Due to their rarity, central registration of parasellar tumours is required in order to be able to provide evidence-based diagnostic and mainly therapeutic approaches.	en
heal.publisher	BIOSCIENTIFICA LTD	en
heal.journalName	ENDOCRINE-RELATED CANCER	en
dc.identifier.isi	ISI:000262590500004	en
dc.identifier.volume	15	en
dc.identifier.issue	4	en
dc.identifier.spage	885	en
dc.identifier.epage	903	en