Environmental distribution, biological role and toxicity of selenium species

Tsopelas, F; Tsantili-Kakoulidou, A; Ochsenkuhn-Petropoulou, M

dc.contributor.author	Tsopelas, F	en
dc.contributor.author	Tsantili-Kakoulidou, A	en
dc.contributor.author	Ochsenkuhn-Petropoulou, M	en
dc.date.accessioned	2014-03-01T11:46:24Z
dc.date.available	2014-03-01T11:46:24Z
dc.date.issued	2010	en
dc.identifier.issn	11054999	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/37884
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-77955444911&partnerID=40&md5=54b0fb74879937dc05073de8cb6d42d0	en
dc.subject.other	selenium	en
dc.subject.other	antineoplastic activity	en
dc.subject.other	bioaccumulation	en
dc.subject.other	bioavailability	en
dc.subject.other	ecosystem	en
dc.subject.other	endocrine system	en
dc.subject.other	environmental monitoring	en
dc.subject.other	European Union	en
dc.subject.other	food intake	en
dc.subject.other	genital system	en
dc.subject.other	immune system	en
dc.subject.other	medical research	en
dc.subject.other	oxidative stress	en
dc.subject.other	review	en
dc.subject.other	toxicity testing	en
dc.title	Environmental distribution, biological role and toxicity of selenium species	en
heal.type	other	en
heal.publicationDate	2010	en
heal.abstract	Starting with some historical aspects, the present review article provides an overview of the chemistry of Selenium and its predominant species. Its role in the environment as well as its chemical transformations and its potential bioaccumulation in ecosystems are iscussed in details. Further emphasis is given in its biological significance as a trace element of living organisms. In particular the involvement of selenium in the protection against oxidative stress and its beneficial effect on various systems within the organism like the immune system, the reproductive system and the endocrine system are analyzed. The recent research progress on potential anticancer protection of selenium species is also reported. Systematic information on selenium bioavailability is missing while recently a new insight on its metabolism was suggested. Such biological processes are important also for the establishment of the toxicity profile of the various selenium species. To this point, the narrow window in the range between essential and toxic levels and the fact that selenium is taken daily with the food, imply the demand for monitoring of selenium emissions due to human activities and its bioaccumulation. Relevant guidelines have been established by international organizations and the European Union.	en
heal.journalName	Pharmakeftiki	en
dc.identifier.volume	23	en
dc.identifier.issue	1	en
dc.identifier.spage	16	en
dc.identifier.epage	32	en