Coumarin-based drugs: A patent review (2008 - present)

Kontogiorgis, C; Detsi, A; Hadjipavlou-Litina, D

dc.contributor.author	Kontogiorgis, C	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Hadjipavlou-Litina, D	en
dc.date.accessioned	2014-03-01T11:46:40Z
dc.date.available	2014-03-01T11:46:40Z
dc.date.issued	2012	en
dc.identifier.issn	13543776	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/38020
dc.subject	antibacterial	en
dc.subject	anticancer	en
dc.subject	coumarin	en
dc.subject	NFAT-signal inhibitors	en
dc.subject.other	adenosine diphosphate	en
dc.subject.other	calanolide A	en
dc.subject.other	cholinesterase inhibitor	en
dc.subject.other	columbianetin	en
dc.subject.other	coumarin derivative	en
dc.subject.other	dihydroxanthyletin	en
dc.subject.other	ferulenol	en
dc.subject.other	ku 32	en
dc.subject.other	marmesin	en
dc.subject.other	novobiocin	en
dc.subject.other	unclassified drug	en
dc.subject.other	warfarin	en
dc.subject.other	wo 031709	en
dc.subject.other	wo 040153	en
dc.subject.other	Alzheimer disease	en
dc.subject.other	antibacterial activity	en
dc.subject.other	antineoplastic activity	en
dc.subject.other	antiviral activity	en
dc.subject.other	biology	en
dc.subject.other	cardiovascular disease	en
dc.subject.other	cell differentiation	en
dc.subject.other	cytotoxicity	en
dc.subject.other	drug synthesis	en
dc.subject.other	ex vivo study	en
dc.subject.other	hair growth	en
dc.subject.other	human	en
dc.subject.other	immunomodulation	en
dc.subject.other	in vitro study	en
dc.subject.other	in vivo study	en
dc.subject.other	kidney polycystic disease	en
dc.subject.other	microwave irradiation	en
dc.subject.other	Mycobacterium	en
dc.subject.other	neural stem cell	en
dc.subject.other	nonhuman	en
dc.subject.other	patent	en
dc.subject.other	review	en
dc.subject.other	skin pigmentation	en
dc.subject.other	structure activity relation	en
dc.subject.other	T lymphocyte	en
dc.subject.other	thrombocyte aggregation	en
dc.subject.other	treatment outcome	en
dc.subject.other	Animals	en
dc.subject.other	Coumarins	en
dc.subject.other	Drug Design	en
dc.subject.other	Humans	en
dc.subject.other	Molecular Structure	en
dc.subject.other	Patents as Topic	en
dc.subject.other	Structure-Activity Relationship	en
dc.title	Coumarin-based drugs: A patent review (2008 - present)	en
heal.type	other	en
heal.identifier.primary	10.1517/13543776.2012.678835	en
heal.identifier.secondary	http://dx.doi.org/10.1517/13543776.2012.678835	en
heal.publicationDate	2012	en
heal.abstract	Introduction: Coumarins are a group of plant-derived polyphenolic compounds. They belong to the benzopyrones family and possess a wide variety of cytoprotective and modulatory functions, which may be translated to therapeutic potentials for multiple diseases. Their physicochemical properties seem to define the extent of the biological activity. Areas covered: In this review recent patent publications (2008 - 2011), describing coumarins and their derivatives, are analyzed. Synthesis, combinatorial techniques, biological evaluation in vitro/in vivo/ex vivo, e.g. antimitotic, immunomodulating, antiviral, anticancer and cytotoxic agents, as well as some new biological assays, are included. In addition to selected biological data, a wide range of pharmaceutical applications and pharmaceutical compositions are also summarized. Expert opinion: Several natural and synthetic coumarins and derivatives with potent in vivo/in vitro biological responses appear to be promising anticancer activities. Their clinical evaluation will be critical to assess therapeutic utility. The compounds for which the mechanism of action is well defined can serve as lead compounds for the design of new more promising molecules. © Informa UK, Ltd.	en
heal.journalName	Expert Opinion on Therapeutic Patents	en
dc.identifier.doi	10.1517/13543776.2012.678835	en
dc.identifier.volume	22	en
dc.identifier.issue	4	en
dc.identifier.spage	437	en
dc.identifier.epage	454	en