Oxidative stress, DNA damage and repair in carcinogenesis: Have we established a connection?

Georgakilas, AG

dc.contributor.author	Georgakilas, AG	en
dc.date.accessioned	2014-03-01T11:47:07Z
dc.date.available	2014-03-01T11:47:07Z
dc.date.issued	2012	en
dc.identifier.issn	03043835	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/38093
dc.subject	Cancer	en
dc.subject	Carcinogenesis	en
dc.subject	DNA damage	en
dc.subject	DNA repair	en
dc.subject	Oxidative stress	en
dc.title	Oxidative stress, DNA damage and repair in carcinogenesis: Have we established a connection?	en
heal.type	other	en
heal.identifier.primary	10.1016/j.canlet.2012.03.032	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.canlet.2012.03.032	en
heal.publicationDate	2012	en
heal.abstract	The production of a plethora of reactive oxygen and nitrogen species in the cell and tissues as the result of endogenous or exogenous mechanisms and interaction of our cells with the environment define the so called 'oxidative load'. The final balance between the oxidatively-induced stress and the various cellular defense mechanisms draw the picture on the landscape of oxidative injury and biological consequences. In this Special Issue, I have compiled a synthesis of concise reviews by leading experts in their fields. The articles focus on the current status and advances in the various pathways leading to the production of high oxidative stress, DNA damage and its processing in human cells and tissues. Significant mechanistic insights are offered as well as connections with biological and clinical significance. © 2012 Elsevier Ireland Ltd. All rights reserved.	en
heal.journalName	Cancer Letters	en
dc.identifier.doi	10.1016/j.canlet.2012.03.032	en