Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy

Aziz, K; Nowsheen, S; Pantelias, G; Iliakis, G; Gorgoulis, VG; Georgakilas, AG

dc.contributor.author	Aziz, K	en
dc.contributor.author	Nowsheen, S	en
dc.contributor.author	Pantelias, G	en
dc.contributor.author	Iliakis, G	en
dc.contributor.author	Gorgoulis, VG	en
dc.contributor.author	Georgakilas, AG	en
dc.date.accessioned	2014-03-01T11:47:18Z
dc.date.available	2014-03-01T11:47:18Z
dc.date.issued	2012	en
dc.identifier.issn	01637258	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/38119
dc.subject	Cancer	en
dc.subject	DNA damage	en
dc.subject	DNA repair	en
dc.subject	Replication stress	en
dc.subject	Therapy	en
dc.subject.other	bleomycin	en
dc.subject.other	breast cancer resistance protein	en
dc.subject.other	carboplatin	en
dc.subject.other	cisplatin	en
dc.subject.other	DNA base	en
dc.subject.other	DNA topoisomerase	en
dc.subject.other	doxorubicin	en
dc.subject.other	etoposide	en
dc.subject.other	free radical	en
dc.subject.other	hydrogen peroxide	en
dc.subject.other	irinotecan	en
dc.subject.other	iron	en
dc.subject.other	methotrexate	en
dc.subject.other	Mre11 protein	en
dc.subject.other	nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1	en
dc.subject.other	nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor	en
dc.subject.other	platelet derived growth factor receptor	en
dc.subject.other	polycyclic hydrocarbon	en
dc.subject.other	polydeoxyribonucleotide synthase	en
dc.subject.other	pyrimidine	en
dc.subject.other	reactive nitrogen species	en
dc.subject.other	sunitinib	en
dc.subject.other	tar	en
dc.subject.other	taxane derivative	en
dc.subject.other	temozolomide	en
dc.subject.other	topotecan	en
dc.subject.other	unindexed drug	en
dc.subject.other	vasculotropin receptor	en
dc.subject.other	vinyl chloride	en
dc.subject.other	XRCC1 protein	en
dc.subject.other	anaphase	en
dc.subject.other	apoptosis	en
dc.subject.other	cancer cell	en
dc.subject.other	carcinogenesis	en
dc.subject.other	cell cycle checkpoint	en
dc.subject.other	cell cycle S phase	en
dc.subject.other	cell death	en
dc.subject.other	cell phagocytosis	en
dc.subject.other	cell respiration	en
dc.subject.other	cell stress	en
dc.subject.other	chromosome	en
dc.subject.other	chromosome aberration	en
dc.subject.other	deamination	en
dc.subject.other	dietary intake	en
dc.subject.other	DNA adduct	en
dc.subject.other	DNA alkylation	en
dc.subject.other	DNA binding	en
dc.subject.other	DNA cleavage	en
dc.subject.other	DNA cross linking	en
dc.subject.other	DNA damage	en
dc.subject.other	DNA end joining repair	en
dc.subject.other	DNA methylation	en
dc.subject.other	DNA protein complex	en
dc.subject.other	DNA repair	en
dc.subject.other	DNA replication	en
dc.subject.other	DNA strand breakage	en
dc.subject.other	DNA transcription	en
dc.subject.other	drug resistance	en
dc.subject.other	enzyme inhibition	en
dc.subject.other	Fenton reaction	en
dc.subject.other	gene amplification	en
dc.subject.other	gene overexpression	en
dc.subject.other	genomic instability	en
dc.subject.other	genotoxicity	en
dc.subject.other	human	en
dc.subject.other	inflammation	en
dc.subject.other	ionizing radiation	en
dc.subject.other	linear energy transfer	en
dc.subject.other	lipid peroxidation	en
dc.subject.other	mechanical torsion	en
dc.subject.other	mitosis spindle	en
dc.subject.other	molecular diagnosis	en
dc.subject.other	molecularly targeted therapy	en
dc.subject.other	nonhuman	en
dc.subject.other	oxidative stress	en
dc.subject.other	priority journal	en
dc.subject.other	progeny	en
dc.subject.other	prognosis	en
dc.subject.other	protein phosphorylation	en
dc.subject.other	review	en
dc.subject.other	signal transduction	en
dc.subject.other	single stranded DNA break	en
dc.subject.other	smoke	en
dc.subject.other	soot	en
dc.subject.other	tautomerization	en
dc.subject.other	thermal exposure	en
dc.subject.other	ultraviolet A radiation	en
dc.subject.other	ultraviolet B radiation	en
dc.subject.other	virus infection	en
dc.subject.other	Animals	en
dc.subject.other	Antineoplastic Agents	en
dc.subject.other	DNA Damage	en
dc.subject.other	DNA Repair	en
dc.subject.other	Humans	en
dc.subject.other	Neoplasms	en
dc.title	Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy	en
heal.type	other	en
heal.identifier.primary	10.1016/j.pharmthera.2011.11.010	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.pharmthera.2011.11.010	en
heal.publicationDate	2012	en
heal.abstract	DNA is under constant assault from genotoxic agents which creates different kinds of DNA damage. The precise replication of the genome and the continuous surveillance of its integrity are critical for survival and the avoidance of carcinogenesis. Cells have evolved an arsenal of repair pathways and cell cycle checkpoints to detect and repair DNA damage. When repair fails, typically cell cycle progression is halted and apoptosis is initiated. Here, we review the different sources and types of DNA damage including DNA replication stress and oxidative stress, the repair pathways that cells utilize to repair damaged DNA, and discuss their biological significance, especially with reference to cancer induction and cancer therapy. We also describe the main methodologies currently used for the detection of DNA damage with their strengths and limitations. We conclude with an outline as to how this information can be used to identify novel pharmacological targets for DNA repair pathways or enhancers of DNA damage to develop improved treatment strategies that will benefit cancer patients. © 2011 Elsevier Inc. All rights reserved.	en
heal.journalName	Pharmacology and Therapeutics	en
dc.identifier.doi	10.1016/j.pharmthera.2011.11.010	en
dc.identifier.volume	133	en
dc.identifier.issue	3	en
dc.identifier.spage	334	en
dc.identifier.epage	350	en