Επαλήθευση απλοποιημένων μοντέλων Michaelis-Menten

Πατσατζής, Δημήτριος; Patsatzis, Dimitrios

dc.contributor.author	Πατσατζής, Δημήτριος	el
dc.contributor.author	Patsatzis, Dimitrios	en
dc.date.accessioned	2017-07-13T06:48:04Z
dc.date.available	2017-07-13T06:48:04Z
dc.date.issued	2017-07-13
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/45193
dc.identifier.uri	http://dx.doi.org/10.26240/heal.ntua.7197
dc.description	Εθνικό Μετσόβιο Πολυτεχνείο--Μεταπτυχιακή Εργασία. Διεπιστημονικό-Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών (Δ.Π.Μ.Σ.) “Εφαρμοσμένη Μηχανική”	el
dc.rights	Αναφορά Δημιουργού - Μη Εμπορική Χρήση - Παρόμοια Διανομή 3.0 Ελλάδα	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/gr/	*
dc.subject	Ασυμπτωτική Ανάλυση	el
dc.subject	Χημική Κινητική	el
dc.subject	Θεωρία Ιδιόμορφων Διαταρραχών	el
dc.subject	Δύσκαμπτα Συστήματα	el
dc.subject	Απλοποιημένα Μοντέλα	el
dc.subject	Model Reduction	en
dc.subject	CSP	el
dc.subject	Michaelis-Menten	el
dc.subject	PEA/QSSA	el
dc.subject	GSPT	el
dc.title	Επαλήθευση απλοποιημένων μοντέλων Michaelis-Menten	el
dc.title	Validation of Michaelis-Menten reduced models	en
heal.type	masterThesis
heal.classification	BIOCHEMISTRY	en
heal.classification	ASYMPTOTIC THEORY	en
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85014171
heal.classificationURI	http://data.seab.gr/concepts/1ef69ccdd4c60110b3ff694b7f8ee892a83cc29a
heal.language	en
heal.access	free
heal.recordProvider	ntua	el
heal.publicationDate	2017-07
heal.abstract	The intracellular Michaelis-Menten mechanism is one of the most simple and most popular mechanisms in the field of systems biology. Its kinetics is also widely employed in enzymology, pharmacokinetics and ecology. The dynamics of the mechanism has been the subject of an extensive research effort and a large bibliography is currently available. In this work the MM mechanism is analysed with the Computational Singular Perturbation (CSP) method, which is the algorithmic counterpart of geometric asymptotic analysis. CSP is employed for the derivation of new reduced models and the validation of the existing ones, which were derived on the basis of Quasi Steady- State (QSSA) and Partial Equilibrium Approximations (PEA). The main purpose of this work is to establish the validity of (i) the CSP-generated reduced models, by examining their stability and accuracy and (ii) the QSSA and PEA-generated reduced models, by considering the conditions in which CSP simplifies to PEA and QSSA. This work aims to provide robust reduced models, which are valid in large domains of the parameter space.	en
heal.advisorName	Γκούσης, Δημήτρης	el
heal.committeeMemberName	Μπουντουβής, Ανδρέας	el
heal.committeeMemberName	Καραντώνης, Αντώνης	el
heal.academicPublisher	Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Χημικών Μηχανικών	el
heal.academicPublisherID	ntua
heal.numberOfPages	86 σ.	el
heal.fullTextAvailability	true