Computational modeling of cancer stem cells In a vascular growing tumor: A two dimensional continuum level approach

Γιαννακόπουλος, Αθανάσιος; Giannakopoulos, Athanasios

dc.contributor.author	Γιαννακόπουλος, Αθανάσιος	el
dc.contributor.author	Giannakopoulos, Athanasios	en
dc.date.accessioned	2024-04-18T06:35:33Z
dc.date.available	2024-04-18T06:35:33Z
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/59211
dc.identifier.uri	http://dx.doi.org/10.26240/heal.ntua.26907
dc.description	Εθνικό Μετσόβιο Πολυτεχνείο--Μεταπτυχιακή Εργασία. Διεπιστημονικό-Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών (Δ.Π.Μ.Σ.) “Υπολογιστική Μηχανική”	el
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ελλάδα	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/gr/	*
dc.subject	Cancer Stem Cells	en
dc.subject	Modeling	en
dc.subject	Growth Rate	en
dc.subject	Death Rate	en
dc.subject	Tumor	en
dc.subject	Καρκινικά Βλαστοκύτταρα	el
dc.subject	Προσομοίωση	el
dc.subject	Ρυθμός Αναπαραγωγής	el
dc.subject	Ρυθμός Απόπτωσης	el
dc.subject	Όγκος	el
dc.title	Computational modeling of cancer stem cells In a vascular growing tumor: A two dimensional continuum level approach	en
heal.type	masterThesis
heal.classification	Cancer Modeling	en
heal.classification	Μοντελοποίηση Καρκίνου	el
heal.language	en
heal.access	free
heal.recordProvider	ntua	el
heal.publicationDate	2023-11-16
heal.abstract	The purpose of this thesis is to provide new insight on how cancer stem cells (CSCs) affect the progression of a tumor, with the use and expansion of 2D modeling techniques, provided by Hubbard and Byrne 2012. The equations governing cancer dynamics were expanded to incorporate the existence of cancer stem cells, a type of cells whose existence has been questioned and highly researched, since the beginning of 20th Century. Cancer stem cells, highly theorized as the main reason for metastasis, are a very resilient to drugs type of stem cells, which have been for the last years the subject of extended treatment breakthroughs. It is yet a not so well understood how they can be effectively killed, since their resilience to chemotherapy and radiotherapy pushes science to alternative methods of healing. In this study, the mathematics of this resilience becomes the steppingstone for extended research of how cancer stem cells parameters of growth and death are related to those of normal tumor cells. A set of parametric studies is performed, and a basic comparison between two models becomes the main attribute for the depiction of the CSCs inclusive model. Using COMSOL Multiphysics®, an Engineering software, the simulations are carried out by incorporating equations of mass , and momentum balance. A set of parameters is incorporated as well, and mainly three parameters are varied for the results: the probability of asymmetry division, the dimensionless growth rate of CSCs and the dimensionless death rate of CSCs. The final results are discussed, along with some propositions for further research, and accompanying details for the extension of the modeling techniques for therapy.	en
heal.advisorName	Καβουσανάκης, Μιχαήλ	el
heal.committeeMemberName	Χαριτίδης, Κωνσταντίνος	el
heal.committeeMemberName	Παπαδόπουλος, Βησσαρίων	el
heal.academicPublisher	Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Χημικών Μηχανικών	el
heal.academicPublisherID	ntua
heal.numberOfPages	89 σ.	el
heal.fullTextAvailability	false