HEAL DSpace

Computational modeling of cancer stem cells In a vascular growing tumor: A two dimensional continuum level approach

Αποθετήριο DSpace/Manakin

Εμφάνιση απλής εγγραφής

dc.contributor.author Γιαννακόπουλος, Αθανάσιος el
dc.contributor.author Giannakopoulos, Athanasios en
dc.date.accessioned 2024-04-18T06:35:33Z
dc.date.available 2024-04-18T06:35:33Z
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/59211
dc.identifier.uri http://dx.doi.org/10.26240/heal.ntua.26907
dc.description Εθνικό Μετσόβιο Πολυτεχνείο--Μεταπτυχιακή Εργασία. Διεπιστημονικό-Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών (Δ.Π.Μ.Σ.) “Υπολογιστική Μηχανική” el
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ελλάδα *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/gr/ *
dc.subject Cancer Stem Cells en
dc.subject Modeling en
dc.subject Growth Rate en
dc.subject Death Rate en
dc.subject Tumor en
dc.subject Καρκινικά Βλαστοκύτταρα el
dc.subject Προσομοίωση el
dc.subject Ρυθμός Αναπαραγωγής el
dc.subject Ρυθμός Απόπτωσης el
dc.subject Όγκος el
dc.title Computational modeling of cancer stem cells In a vascular growing tumor: A two dimensional continuum level approach en
heal.type masterThesis
heal.classification Cancer Modeling en
heal.classification Μοντελοποίηση Καρκίνου el
heal.language en
heal.access free
heal.recordProvider ntua el
heal.publicationDate 2023-11-16
heal.abstract The purpose of this thesis is to provide new insight on how cancer stem cells (CSCs) affect the progression of a tumor, with the use and expansion of 2D modeling techniques, provided by Hubbard and Byrne 2012. The equations governing cancer dynamics were expanded to incorporate the existence of cancer stem cells, a type of cells whose existence has been questioned and highly researched, since the beginning of 20th Century. Cancer stem cells, highly theorized as the main reason for metastasis, are a very resilient to drugs type of stem cells, which have been for the last years the subject of extended treatment breakthroughs. It is yet a not so well understood how they can be effectively killed, since their resilience to chemotherapy and radiotherapy pushes science to alternative methods of healing. In this study, the mathematics of this resilience becomes the steppingstone for extended research of how cancer stem cells parameters of growth and death are related to those of normal tumor cells. A set of parametric studies is performed, and a basic comparison between two models becomes the main attribute for the depiction of the CSCs inclusive model. Using COMSOL Multiphysics®, an Engineering software, the simulations are carried out by incorporating equations of mass , and momentum balance. A set of parameters is incorporated as well, and mainly three parameters are varied for the results: the probability of asymmetry division, the dimensionless growth rate of CSCs and the dimensionless death rate of CSCs. The final results are discussed, along with some propositions for further research, and accompanying details for the extension of the modeling techniques for therapy. en
heal.advisorName Καβουσανάκης, Μιχαήλ el
heal.committeeMemberName Χαριτίδης, Κωνσταντίνος el
heal.committeeMemberName Παπαδόπουλος, Βησσαρίων el
heal.academicPublisher Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Χημικών Μηχανικών el
heal.academicPublisherID ntua
heal.numberOfPages 89 σ. el
heal.fullTextAvailability false


Αρχεία σε αυτό το τεκμήριο

Οι παρακάτω άδειες σχετίζονται με αυτό το τεκμήριο:

Αυτό το τεκμήριο εμφανίζεται στην ακόλουθη συλλογή(ές)

Εμφάνιση απλής εγγραφής

Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ελλάδα Εκτός από όπου ορίζεται κάτι διαφορετικό, αυτή η άδεια περιγράφεται ως Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ελλάδα